Diazepam is N-demethylated by CYP3A4 and 2C19 to your Energetic metabolite N-desmethyldiazepam, and is hydroxylated by CYP3A4 towards the Lively metabolite temazepam. N-desmethyldiazepam and temazepam are the two more metabolized to oxazepam. Temazepam and oxazepam are mostly eliminated by glucuronidation.
地西泮脂溶性较高，肌肉注射吸收慢而不规则，也不完全，血浓度不稳定，其峰值血药浓度比口服还低，故临床上一般不宜采用肌肉注射的方法给药。
Unique attention should be compensated to respiratory and cardiac function in intense care. Standard supportive steps must be employed, together with intravenous fluids, and an satisfactory airway maintained. Should really hypotension acquire, treatment may well include things like intravenous fluid therapy, repositioning, considered use of vasopressors correct to your clinical predicament, if indicated, together with other ideal countermeasures. Dialysis is of restricted value.
“Prior to I had been discharged from the clinic, a neurologist officially diagnosed me by using a seizure disorder.”
次にクロロ酢酸クロリドとのショッテン・バウマン反応によりアミノ基をクロロアセチル化する。さらに水酸化ナトリウム存在下で反応させると、オキシム窒素のクロロアセチル基への求核置換が起こり、ベンゾジアゼピン骨格が形成される。なお、スターンバックらはこの化合物の合成法について、同じ文献上でいくつかの別法も報告している。
In depth accumulation of diazepam and its big metabolite, desmethyldiazepam, is observed adhering to chronic administration of diazepam in balanced elderly male topics. Metabolites of this drug are known to generally be substantially excreted check here from the kidney, and the potential risk of toxic reactions could be higher in people with impaired renal function.
ジヒドロエルゴリン（英語版）類 (例：ジヒドロエルゴクリプチン（英語版）, エルゴロイド（英語版）)
テキストはクリエイティブ・コモンズ 表示-継承ライセンスのもとで利用できます。追加の条件が適用される場合があります。詳細については利用規約を参照してください。
Diazepam is very lipid-soluble and is broadly dispersed all through the overall body right after administration. It quickly crosses the two the blood–brain barrier as well as the placenta, and it is excreted into breast milk.
Individuals who have a background of, or now are afflicted by the following Actual physical health problems need to seek the advice of their Health care supplier in advance of getting diazepam:
Our strategy facilities on managing people with the same kindness and respect that we benefit for ourselves. We fully grasp mental health and fitness problems firsthand and aid your pursuit of effectively-staying with compassion.
I had a Seizure Motion Program that I skilled Individuals around me to use when I experienced a seizure, but I continue to didn’t come to feel self-confident in my ability to Manage my seizures.” Newfound self-confidence with VALTOCO
Should you abruptly cease taking diazepam after quite a few months of procedure, you would possibly knowledge withdrawal signs which could make your pregnancy more difficult.
Diazepam isn't going to have an affect on the functioning of any sort of contraception such as the start Command products and crisis contraception. Delivery Regulate products can keep Diazepam in The body for a long period and improve its effect.